Sheffield United manager Chris Wilder has made five changes after a 3-2 midweek loss at Crystal Palace left the Blades rooted to the foot of the Premier League table.
Deadline day signing Mason Holgate starts, while goalkeeper Wes Foderingham replaces January signing Ivo Grbic after he suffered a concussion against Palace.
William Osula, Rhys Norrington-Davies and Andre Brooks all also come in as Jack Robinson and Gustavo Hamer drop to the bench – and Oli McBurnie and Anis Ben Slimane miss out.
Sheffield United XI: Foderingham, Bogle, Ahmedhodzic, Holgate, Trusty, Souza, McAtee, Norrington-Davies, Brooks, Brereton, Osula.
Unai Emery makes two changes to the Aston Villa side which lost 3-1 at home to Newcastle on Tuesday.
Diego Carlos and Leon Bailey come in for Matty Cash and Moussa Diaby.
January signing Morgan Rogers starts on the bench.
Aston Villa XI: Martinez, Konsa, Carlos, Lenglet, Moreno, McGinn, Kamara, Luiz, Tielemans, Bailey, Watkins.